Bifidobacterium longum

1714® (Zenbiome Cope™ & Sleep™)

4 weeks

Placebo-controlled study

22 participants

1714® strain supported cortisol levels and reduced perceived stress levels throughout the study compared to the placebo group.

Significantly lower perceived stress levels in those participants taking B. longum 1714® compared to the placebo group. Bifidobacterium longum 1714® (Zenbiome Cope™ & Sleep™)

DOI: 10.1038

Bifidobacterium longum

1714® (Zenbiome Cope™ & Sleep™)

4 weeks

Randomized, double-blinded,

placebo-controlled trial

40 participants

1714® strain supported relaxation reduced stress, and enhanced mood

Difference of neural activity change during resting state in theta band after 1714®- promoted theta brainwave activity at rest, compared to the placebo group.

Difference of neural activity change during resting state in beta 2 band after 1714® supported body’s adaptation to beta 2 brain wave activity at rest, compared to the placebo group.

DOI: 10.14309

Form/ Duration

Study Details and Results

References

Bifidobacterium longum

1714® (Zenbiome Cope™ & Sleep™) 4 weeks

Double-blind, randomized,

placebo-controlled, repeated

measures, cross-over design

20 participants

Overall sleep quality and duration of sleep improved significantly in the probiotic treated group during exam stress compared with the placebo treated group.

DOI: 10.1016

Bifidobacterium longum 1714® and Bifidobacterium longum 35624® (Zenbiome Cope™ & Sleep™)

8 weeks

Open label exploratory study

40 participants

This exploratory open-label study found that 82% of subjects had significantly improved issues after 8 weeks, with 66% of subjects significantly improving after 4-weeks (issue severity score change of ≥ 50) in the moderate to severe group. The combination solution improved each of the individual issues (occasional abdominal discomfort, distension, bowel satisfaction), as well as an improvement in their quality of life. Participants in this group also had a significant improvement in their morning cortisol awakening response, a physiological biomarker of stress, after 4-weeks.

DOI: 10.111