Vitamin D3 5,000 Progressive Labs

Description

Description

Vitamin D is a fat-soluble vitamin that is found only in small amounts in certain foods.  Our bodies can also make vitamin D when exposed to sunshine (hence why vitamin D is often referred to as the sunshine vitamin).  Vitamin D is considered an essential nutrient because we need to obtain it from food or with the assistance of sunshine which allows our body to manufacture vitamin D.‡

Vitamin D is often found in supplements, and may be found in two forms: vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol).  Our body produces vitamin D3 (cholecalciferol) which is easily absorbed and used in many biological functions.  The D2 version of vitamin D can not be used by the body, and must be converted to D3 for use.   While we are able to convert some D2 to be used for body functions, we use D3 much more effectively.‡

Vitamin D is necessary for good health.  It helps your body absorb calcium, one of the main building blocks for strong bones.   A deficiency of vitamin D can lead to a condition called rickets in children, it can cause rickets which is a rare disease that causes the bones to become soft and bend.  Low vitamin D also leads to poor absorption of calcium which can lead to osteoporosis.‡

Your body needs vitamin D for other functions too.  Your muscles need it to move, and your nerves need it to carry messages between your brain and your body. Your immune system needs vitamin D to fight off invading bacteria and viruses.‡

 

 

Warning:  If you are pregnant or lactating woman, have any health conditions, or are taking any medication, make sure to consult your healthcare provider prior to use.

‡ These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure or prevent any disease.

Ingredients

Dosage

One softgel capsule daily.

Count

100 Softgel Capsules

Science

Holick MF. Vitamin D deficiency. New England Journal of Medicine. 2007 Jul 19;357(3):266-81.

Mitri J, Pittas AG. Vitamin D and diabetes. Endocrinol Metab Clin North Am. 2014 Mar;43(1):205-32.

Elamin MB, Abu Elnour NO, Elamin KB, Fatourechi MM, Alkatib AA, Almandoz JP, Liu H, Lane MA, Mullan RJ, Hazem A, Erwin PJ. Vitamin D and cardiovascular outcomes: a systematic review and meta-analysis. The Journal of Clinical Endocrinology & Metabolism. 2011 Jul 1;96(7):1931-42.

Martens PJ, Gysemans C, Verstuyf A, Mathieu AC. Vitamin D’s Effect on Immune Function. Nutrients. 2020 Apr 28;12(5):1248. doi: 10.3390/nu12051248. PMID: 32353972; PMCID: PMC7281985.

Chen, J., Mei, K., Xie, L. et al. Low vitamin D levels do not aggravate COVID-19 risk or death, and vitamin D supplementation does not improve outcomes in hospitalized patients with COVID-19: a meta-analysis and GRADE assessment of cohort studies and RCTs. Nutr J 20, 89 (2021). https://doi.org/10.1186/s12937-021-00744-y

D’Souza RS, Lin G, Oh T, Vincent A, Orhurhu V, Jiang L, Mauck WD, Qu W. Fibromyalgia Symptom Severity and Psychosocial Outcomes in Fibromyalgia Patients with Hypovitaminosis D: A Prospective Questionnaire Study. Pain Med. 2020 Dec 25;21(12):3470-3478. doi: 10.1093/pm/pnz377. PMID: 32022867.

Lotfi-Dizaji L, Mahboob S, Aliashrafi S, Vaghef-Mehrabany E, Ebrahimi-Mameghani M, Morovati A. Effect of vitamin D supplementation along with weight loss diet on meta-inflammation and fat mass in obese subjects with vitamin D deficiency: A double-blind placebo-controlled randomized clinical trial. Clin Endocrinol (Oxf). 2019 Jan;90(1):94-101. doi: 10.1111/cen.13861. Epub 2018 Nov 12. PMID: 30246883.

Vitamin D: Fact sheet for health professionals. Office of Dietary Supplements. https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/.

Hassan-Smith ZK, Jenkinson C, Smith DJ, Hernandez I, Morgan SA, Crabtree NJ, Gittoes NJ, Keevil BG, Stewart PM, Hewison M. 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 exert distinct effects on human skeletal muscle function and gene expression. PLoS One. 2017 Feb 15;12(2):e0170665. doi: 10.1371/journal.pone.0170665. PMID: 28199350; PMCID: PMC5310904.

LeBoff MS, Chou SH, Ratliff KA, et al. Supplemental Vitamin D and Incident Fractures in Midlife and Older Adults. The New England Journal of Medicine. July 2022.

Evaluation, Treatment, and Prevention of Vitamin D Deficiency: An Endocrine Society Clinical Practice Guideline. The Journal of Clinical Endocrinology & Metabolism. July 2011.

Bolland M, Grey A, Avenell A. Effects of Vitamin D Supplementation on Musculoskeletal Health: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis. The Lancet Diabetes & Endocrinology. November 2018.

Mikola T, Marx W, Lane MM, et al. The Effect of Vitamin D Supplementation on Depressive Symptoms in Adults: A Systematic Review and Meta-Analysis of Randomized, Controlled Trials. Critical Reviews in Food Science and Nutrition. July 2022.

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