GABA-Val® Progressive Labs

Description

Description

Gamma-aminobutyric acid (GABA) is a neurotransmitter, or chemical messenger, in the brain.   It is a natural calming and anti-epileptic agent made in the brain that is manufactured from glutamine and glucose.  The brain contains many neurotransmitters that trigger or inhibit specific reactions in the body.  GABA calms the nervous system by preventing the transmission of certain signals. ‡

GABA is the primary inhibitory neurotransmitter in the central nervous system and participates in cell-to-cell communication.  Healthy GABA levels have been associated with positive mood.  A recent study indicates that GABA also enhances alpha wave production in the brain to promote relaxation and moderate occasional stress.  In the same study, it supported healthy IgA levels, suggesting that it may support immune health during occasional stress.‡

Too much excitation can lead to irritability, restlessness, sleeplessness, and spasmodic movements which requires balancing.  GABA, as an inhibitory neurotransmitter, can provide this balance.  Studies also indicate GABA can promote relaxation and enhance sleep.  Research indicates that low GABA levels or decreased GABA function in the brain may have an adverse impact on neurological health.‡

GABA-Val® also includes valerian root, which is one of the most widely studied herbs for its beneficial effects on the nervous system.  Valerian contains valerenic acid which is only found in this herb.  Valerian is the perfect adjunct to GABA as it is believed to enhance the release of the neurotransmitter GABA, which may explain its ability to help promote sleep and relaxation.‡

Also contains the herbs hops and passion flower extracts which have been shown to support sleep and relaxation, as well as milk protein hydrosylate.‡

 

 

Warning:  If you are pregnant or lactating woman, have any health conditions, or are taking any medication, make sure to consult your healthcare provider prior to use.

‡ These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure or prevent any disease.

Ingredients

Dosage

Two vegetable capsules daily between meals.

Count

60 Vegetable Capsules

Science

Allen MJ, Sabir S, Sharma S. GABA Receptor. [Updated 2023 Feb 13]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https:///books/NBK526124/

Ngo, D.-H.; Vo, T.S. An Updated Review on Pharmaceutical Properties of Gamma-Aminobutyric Acid. Molecules 2019, 24, 2678. https://doi.org/10.3390/molecules24152678

Steenbergen, L., Sellaro, R., Stock, AK. et al. RETRACTED ARTICLE: γ-Aminobutyric acid (GABA) administration improves action selection processes: a randomised controlled trial. Sci Rep 5, 12770 (2015). https://doi.org/10.1038/srep12770

Yoto, A., Murao, S., Motoki, M. et al. Oral intake of γ-aminobutyric acid affects mood and activities of central nervous system during stressed condition induced by mental tasks. Amino Acids 43, 1331–1337 (2012). https://doi.org/10.1007/s00726-011-1206-6

Boonstra E, de Kleijn R, Colzato LS, Alkemade A, Forstmann BU, Nieuwenhuis S. Neurotransmitters as food supplements: the effects of GABA on brain and behavior. Front Psychol. 2015 Oct 6;6:1520. doi: 10.3389/fpsyg.2015.01520. PMID: 26500584; PMCID: PMC4594160.

Todd N, Zhang Y, Power C, Becerra L, Borsook D, Livingstone M, McDannold N. Modulation of brain function by targeted delivery of GABA through the disrupted blood-brain barrier. Neuroimage. 2019 Apr 1;189:267-275. doi: 10.1016/j.neuroimage.2019.01.037. Epub 2019 Jan 16. PMID: 30659957; PMCID: PMC6422703.

Hepsomali P, Groeger JA, Nishihira J, Scholey A. Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review. Front Neurosci. 2020 Sep 17;14:923. doi: 10.3389/fnins.2020.00923. PMID: 33041752; PMCID: PMC7527439.

Hepsomali P, Groeger JA, Nishihira J, Scholey A. Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review. Front Neurosci. 2020 Sep 17;14:923. doi: 10.3389/fnins.2020.00923. PMID: 33041752; PMCID: PMC7527439.

Briguglio M, Dell’Osso B, Panzica G, Malgaroli A, Banfi G, Zanaboni Dina C, Galentino R, Porta M. Dietary Neurotransmitters: A Narrative Review on Current Knowledge. Nutrients. 2018 May 10;10(5):591. doi: 10.3390/nu10050591. PMID: 29748506; PMCID: PMC5986471.

Shinjyo N, Waddell G, Green J. Valerian Root in Treating Sleep Problems and Associated Disorders-A Systematic Review and Meta-Analysis. J Evid Based Integr Med. 2020 Jan-Dec;25:2515690X20967323. doi: 10.1177/2515690X20967323. PMID: 33086877; PMCID: PMC7585905.

Becker A, Felgentreff F, Schröder H, Meier B, Brattström A. The anxiolytic effects of a Valerian extract is based on valerenic acid. BMC Complement Altern Med. 2014 Jul 28;14:267. doi: 10.1186/1472-6882-14-267. PMID: 25066015; PMCID: PMC4122768.

Roh D, Jung JH, Yoon KH, Lee CH, Kang LY, Lee SK, Shin K, Kim DH. Valerian extract alters functional brain connectivity: A randomized double-blind placebo-controlled trial. Phytother Res. 2019 Apr;33(4):939-948. doi: 10.1002/ptr.6286. Epub 2019 Jan 10. PMID: 30632220.

Mineo L, Concerto C, Patel D, Mayorga T, Paula M, Chusid E, Aguglia E, Battaglia F. Valeriana officinalis Root Extract Modulates Cortical Excitatory Circuits in Humans. Neuropsychobiology. 2017;75(1):46-51. doi: 10.1159/000480053. Epub 2017 Oct 17. PMID: 29035887.

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